ChEMBL

We are pleased to announce the release of ChEMBL_10. This latest version of the ChEMBL database contains:

• 1,118,566 compound records
• 1,000,468 distinct compounds
• 534,391 assays
• 4,668,202 bioactivities
• 8,372 targets
• 40,624 documents
• 6 data sources

This release of the ChEMBL database contains a subset of the data from the PubChem BioAssay database. Specifically, we have included dose-response endpoints (e.g., IC₅₀, Ki, Potency) from confirmatory assays in PubChem - the aim of this is to integrate data that is comparable to the type and class of data contained within ChEMBL. This subset contains:

• 333,864 compound records (PubChem Substance entries)
• 794 assays (PubChem BioAssay assays)
• 1,473,189 bioactivities (IC₅₀ etc. measurements)

You can access the data via the ChEMBL database interface: http://www.ebi.ac.uk/chembldb/index.php.

Changes to the interface include:

• 'Activity Source Filter' link has been added to the main search bar to allow users to include/exclude activity sources (e.g. PubChem BioAssay, Literature, ...) in the current working session

• Links to Wikipedia, DrugBank, PubChem and PDBe are now included in report card pages.

You can download the data from the ChEMBL ftpsite: ftp://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/latest/

 All other ChEMBL resources (e.g. Web Services) are also now connected to ChEMBL_10.