Current GPCR X-ray structures

As part of resurrecting GPCR SARfari from the ashes, we needed to refresh the protein structure content. There are now a surprisingly large number of distinct X-ray family A, rhodopsin-like GPCR structures known, of course it is never enough, but large nonetheless. There are five distinct proteins (bovine and squid rhodopsin, human beta-2 adrenergic receptor, turkey beta-1 adrenergic receptor and human Adenosine A2A receptor. These are known in a variety of different liganded states, crystal forms, resolutions, and also with differing numbers of distinct chains within crystallographic assymmetric units. So in total, there are 27 distinct X-ray PDB entries and 45 distinct GPCR domain structures.

Here is a table, as of 27th August 2010.

PDB codeCh.ProteinLigandSpeciesRes.Date
1f88ARhodopsinretinalBos taurus2.84 Aug 2000
1f88BRhodopsinretinalBos taurus2.84 Aug 2000
1gzmARhodopsinretinalBos taurus2.620 Nov 2003
1gzmBRhodopsinretinalBos taurus2.620 Nov 2003
1hzxARhodopsinretinalBos taurus2.84 Jul 2001
1hzxBRhodopsinretinalBos taurus2.84 Jul 2001
1l9hARhodopsinretinalBos taurus2.615 May 2002
1l9hBRhodopsinretinalBos taurus2.615 May 2002
1u19ARhodopsinretinalBos taurus2.212 Oct 2004
1u19BRhodopsinretinalBos taurus2.212 Oct 2004
2g87ARhodopsinretinalBos taurus2.62 Mar 2006
2g87BRhodopsinretinalBos taurus2.62 Mar 2006
2hpyARhodopsinretinalBos taurus2.818 Jul 2006
2hpyBRhodopsinretinalBos taurus2.818 Jul 2006
2pedARhodopsinretinalBos taurus2.92 Apr 2007
2pedBRhodopsinretinalBos taurus2.92 Apr 2007
2i36ARhodopsinapoBos taurus4.117 Oct 2006
2i36BRhodopsinapoBos taurus4.117 Oct 2006
2i36CRhodopsinapoBos taurus4.117 Oct 2006
2i37ARhodopsinapoBos taurus4.117 Oct 2006
2i37BRhodopsinapoBos taurus4.117 Oct 2006
2i37CRhodopsinapoBos taurus4.117 Oct 2006
2j4yARhodopsinretinalBos taurus3.425 Sep 2007
2j4yBRhodopsinretinalBos taurus3.425 Sep 2007
3capARhodopsinapoBos taurus2.924 Jun 2008
3capBRhodopsinapoBos taurus2.924 Jun 2008
3c9lARhodopsinretinalBos taurus2.65 Aug 2008
3c9mARhodopsinretinalBos taurus3.416 Feb 2008
3dqbARhodopsinapoBos taurus3.223 Sep 2008
2z73ARhodopsinretinalTodarodes pacificus2.513 May 2008
2z73BRhodopsinretinalTodarodes pacificus2.513 May 2008
2ziyARhodopsinretinalTodarodes pacificus3.727 Feb 2008
2r4rAbeta-2 adrenergic receptorapoHomo sapiens3.46 Nov 2007
2r4sAbeta-2 adrenergic receptorapoHomo sapiens3.46 Nov 2007
2rh1Abeta-2-adrenergic receptorCarazololHomo sapiens2.430 Oct 2007
3d4sAbeta-2 adrenergic receptorTimololHomo sapiens2.817 Jun 2008
3kj6Abeta-2 adrenergic receptorapoHomo sapiens3.416 Feb 2010
3ny8Abeta-2 adrenergic receptorICI-118551Homo sapiens2.811 Aug 2010
3ny9Abeta-2 adrenergic receptornovel analog of ICI-118551Homo sapiens2.811 Aug 2010
3nyaAbeta-2 adrenergic receptorAlprenololHomo sapiens3.211 Aug 2010
2vt4Abeta-1 adrenergic receptorCyanopindololMeleagris gallopavo2.724 Jun 2008
2vt4Bbeta-1 adrenergic receptorCyanopindololMeleagris gallopavo2.724 Jun 2008
2vt4Dbeta-1 adrenergic receptorCyanopindololMeleagris gallopavo2.724 Jun 2008
2vt4Cbeta-1 adrenergic receptorCyanopindololMeleagris gallopavo2.724 Jun 2008
3emlAAdenosine A2a receptorZM-241385Homo sapiens2.614 Oct 2008