GPCR Structure: Human CXCR1 receptor
Hot on the heels of this years Nobel Prize for Chemistry awarded for structural studies on GPCRs, there's a brand new GPCR structure - human CXCR1, this time an NMR one, published in Nature. The PDBe code is 2lnl. This brings the total to 16 sequence distinct rhodopsin-like GPCR structures that we now have free access to.
%T Structure of the chemokine receptor CXCR1 in phospholipid bilayers %A S.H. Park %A B.B. Das %A F. Casagrande %A Y. Tian %A H.J. Nothnagel %A M. Chu %A H. Kiefer %A K. Maier %A A.A. De Angelis %A F.M. Marassi %A S.J. Opella %J Nature %D 2012
%V 491
%P 779-783 %O doi:10.1038/nature11580
- 3uon - human muscarinic M2 receptor
- 4daj - rat muscarinic M3 receptor
- 3rze - human histamine H1 receptor
- 2rh1 - human beta-2 adrenergic receptor
- 2vt4 - turkey beta-1 adrenergic receptor
- 3pbl - human dopamine D3 receptor
- 2ydv - human adenosine A2a receptor
- 3v2w - human sphingosine-1-phosphate receptor
- 4djh - human kappa opioid receptor
- 4dkl - mouse mu opioid receptor
- 4ej4 - mouse delta opioid receptor
- 4ea3 - human nociceptin receptor
- 3odu - human CXCR4 receptor
- 2lnl - human CXCR1 receptor (NMR)
- 2i35 - bovine rhodopsin
- 2z73 - squid rhodopsin
10 20 30 40 50 60 70 3uon ( 20 ) tfevvfivlvagslSlvTiigNilVmvSI 4dajA ( 64 ) iwqvvfiafltgflAlvTiigNilVivAF 3rze ( 28 ) mplvvvlsticlvTvglNllVlyAv 2rh1 ( 29 ) devwvvgmgivmslivlaIvfgNvlVitAI 2vt4A ( 40 ) weagmsllmalVvllIvagNvlViaAi 3pblA ( 32 ) yalsYcalilaIvfgNglVcmAV 2ydv ( 3 ) imgssvYitvElaiavlAilgNvlVcwAv 3v2w ( 17 ) sdyvnydIIvrHYnyTgklnisa ltsvvfiliCcfIileNifvllti 4djhA ( 55 ) spaipviitavysvvfvvGlvgNslVmfVI 4dkl ( 65 ) mvtaitimalYsiVcvvGlfgNflvmyvI 4ej4 ( 41 ) rsasslalaiaitalYsavcavGllgNvlvmfgI 4ea3A ( 47 ) plglkvtIvglYlavcvgGllgNclvmyVI 3oduA ( 27 ) pçfre-------------------------enanfnkiflptiYsiIfltGivgNglvilvM 2lnl ( 29 ) pÇmle--------------------------tetLnkYvviiayalvFllsllgNslvMlvi 1u19A ( 1 ) mnGtegpnfyVPfsnktgvVrsPFeapQyyLaepwqFsmlAayMflLimlGfpiNflTlyVT 2z73A ( 9 ) etwwyNpsIvVhpHWref--------------dqvpdavYyslGifIgiCgiiGcggNgiViyLF aaaaaaaaaaaaaaaaaaaaaaaaaa 80 90 100 110 120 130 140 3uon ( 49 ) kvnrhLqtvnnyflfSLAcADliiGvfSMnlytlytvi-gyWplgpvvÇdlWlalDYvVSNAsVmNLlii 4dajA ( 93 ) kvnkqLktvnnyFllSLAcADliIGviSMnlFttyiim-nrWalgnlaÇdlwLSiDYvASNAsVmNLlvI 3rze ( 53 ) rserkLhtvGnlYIvsLSvADliVGavVMpmnilyllm-skwsLgrplÇlfWLSmDYVASTASIfSVfiL 2rh1 ( 59 ) akferLqtvtnyFItsLAcADlvMGlaVVpfgaahilm-kmWtfgnfwçefWTSiDVlCVTASIeTLcvI 2vt4A ( 67 ) gstqrLqtltnlFItsLAcADlvvGllVVpfgatlvvr-gtWlwgsflçelWTSlDVlCVTAsIeTLcvI 3pblA ( 55 ) lkeraLqtttnyLVvsLAvADllvAtlVMpwvvylevtggvWnfsricÇdvFVTlDVmMcTAsIwNLCaI 2ydv ( 32 ) wlnsnLqnvtnyFVvsAAaADilVGvlAIpfaiaIst---GfçaaçhgÇLfiACfVLVLTASSIfSLlaI 3v2w ( 71 ) wktkkFhrpMYyFIgnLAlSDllaGvaYtaNlllsga--tTykLtPaqWFlREGsMFvALSASVfSLlaI 4djhA ( 85 ) irytkmktaTniYIfNLAlADalVTtTMpfqstvylmn--sWpfgdvlÇkiVlsiDyyNMfTSIfTLtmM 4dkl ( 94 ) vrytkMktAtniYIfNLAlADalATsTLpfqsvnylmg--tWpfgnilÇkiviSidYyNMFTSIfTLctM 4ej4 ( 75 ) vrytkLktATniYIfNLAlADalATstLpfqsakylme--tWpfgellÇkaVlSidYyNMFTSIfTLtmM 4ea3A ( 77 ) lrhtkmktatNiYIfNLAlADtlVLlTLpfQGtdillg--fWpfgnalÇktVIaiDyyNMFTSTfTLtaM 3oduA ( 64 ) gyqkklrsmtdkYRlhLSvADllFVitLpfWavDAva---nWyfgnflÇkaVHviYTVNlYSSVwILAfI 2lnl ( 65 ) lysrvGrsvTdvyLlnLalaDllfaltlpiwaaSkvn---gwifgtfLÇkvVslLkEvnfYsgilLlacI 1u19A ( 63 ) vqHkkLrtplNyILlnLAvADlfMVfg-GFtTTlyTSlhGyFvfgptGÇnlEGffATLGGEIaLWSLvvL 2z73A ( 60 ) tktksLqtpanmFiinLAfSDftFSlvNGfplMtiSCflkkWifgfaaÇkvYGfiGGiFGFMsIMTMAMi aa aaaaaaaaaaaaaaaaaa aaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaa 150 160 170 180 190 200 210 3uon ( 118 ) Sfdryfcvtkpltypvk---rttkmAgmmiaaAwvlSfilwapaIlfwqfivg-----------vrtVed 4dajA ( 162 ) SfDryfsitrpltyrak---rttkrAgvmiglAwviSfvlWApaIlfwqyfvg-----------krtVpp 3rze ( 122 ) CiDryrsvqqplrylky---rtktrAsatilgawflSfl-WvipIlgwnh rre 2rh1 ( 128 ) AvdryfAItspfkyqSl---ltknkArviilmvwivSgltSflpIqmhwyr-----athqeAinÇyae-e 2vt4A ( 136 ) AiDrylaitspfryqsl---mtrarAkviictvwaiSalvSflpImmhwWr-----dedpqAlkçyqd-p 3pblA ( 125 ) SidRytAVvmpvhyqhgtgqsscrrValmitavwvlAfaVSc-pLlfgfNtTg---------------dp 2ydv ( 99 ) AiDryiairiplryngl---vtgtrAkgiiaicwvlSfaIGltPmlgwnnÇgqp--kegkahsqgÇgegq 3v2w ( 139 ) Aieryitmlk nnfrlfllisacwviSlilGglPimgwn---------------Çisals 4djhA ( 153 ) SvdRyiaVchpvkaldf---rtplkAkiinicIwllSssvGisAivlGGtkvred------------vdv 4dkl ( 162 ) SvdRyiAVChpvkaldf---rtprnAkivnvcNwilSsaiGlpVmfmAttkyrqg--------------s 4ej4 ( 143 ) SvDRyiavchpvkaldf---rtpakAklinicIwvlAsgvGvpimvmAvtqprdg--------------a 4ea3A ( 145 ) Svdryvaichp tsskAqavnvaIwalAsvvGvpvaimGsAqvede--------------e 3oduA ( 131 ) SlDRylAiVhatn---sqrprkllAekvVyvgVwipAlllT-ipDfif--Anvsead-----------dr 2lnl ( 132 ) svdrylaivhaTr----tltqkrhlvkfvclgcwglsmnlS-lpFflf--RQayhpN----------NsS 1u19A ( 132 ) aieRyvvVckpmsn----frfgenhaimgvafTwvmAlaCAapPlvgwSrYIPE-------------GMQ 2z73A ( 130 ) SiDrynViGrpmaas---kkMshrrAfimiifVwlwSvlwAigPifgwGaYtLE-------------GVL aaaaaaaa aaaaaaaaaaaaaaaaaaa aaa 220 230 240 250 260 270 280 3uon ( 174 ) geÇyIqff------snaavtfgtAiaaFylpviiMtvlywhisrasksri p 4dajA ( 218 ) geÇfIqfl------septitfgtAiaaFymPvtiMtilywrIyketek 3rze ( 178 ) dkÇeTdfy------dvtwfkvmtaiinFylPtllMlwfyakIykaVrqhc l 2rh1 ( 189 ) tçÇdff--------TnqayaiasSivSFyvplviMvfvYsrVfqeakrql k 2vt4A ( 197 ) gçÇdfv--------TnrayaiasSiiSFyipLliMifvalrvyreakeq 3pblA ( 179 ) tvÇsIs---------npdFViySSvvSFylPfgvTvlvyarIyvvlkqrrrk-----------------g 2ydv ( 164 ) vAÇlFedVV-----pmnYMVyfNffaCVlvPlllMlgvylrIflaarrqlkqmesq s 3v2w ( 190 ) sÇSTVLP-------LYhkhYIlfCTtvFtllllsIvilYcriyslvrtr as 4djhA ( 208 ) ieÇslqFpdddyswwdlfmkicVfifAfviPvliIivcytlMilrlksvrllsg re 4dkl ( 215 ) idçtltfsh-ptwywenllKicVfifAfimPvliItvcyglmilrlksvr e 4ej4 ( 196 ) vvÇmlqfps-pswywdtvtkicvflfAfvvPiliitvcyglMllrlrsvr e 4ea3A ( 198 ) ieÇlveipt-pqdywgpvfaiciflfSFivPvlvIsvcyslMirrlrgvrlls-------------gsre 3oduA ( 184 ) yiÇdrfyp---ndlwvvvfqfqhimvglilPgivIlsCyciIisklshs 2lnl ( 185 ) PvÇyEVlg-ndtakwrmvLrilPHtfGfivplfvmlfcygftlrtlf---------------------ka 1u19A ( 185 ) CSÇGIDYYTpheetnNesFViyMfvvHfiiPlivIffcygqLvftvkeaaaq------------qqesat 2z73A ( 184 ) CNÇSFdYIsr--dsttrsNIlcMFilGffgPiliiffCyfnIvmsvsnhekemaamakrlnakelrkaqa aaaaaaaaaa aaaaaaaaaaaaaaaaa 290 300 310 320 330 340 350 3uon ( 378 ) ppsrekkvtrtilaIllaFiitWapYNvmVlintfçap--------ç--ipntvwtiGywlCYinstiNp 4dajA ( 482 ) like aqTlsaIllaFiitWtpyNimVlvntfçds--------ç--ipktywnlgywlCYiNStvNP 3rze ( 406 ) hmnrerkaakQLgfIMaaFilCWipYFiffmviafçkn--------ç--cnehlhmftiWlGYiNStlNP 2rh1 ( 264 ) fclkeHkaLktlgiIMgtFtlcWlpFFiVNivhviqdn----------lirkevyillNwiGYvNSgfNp 2vt4A ( 238 ) irehkalktlgiImgvFtlCWlpFFlvnivnvfnrd----------lvpdwlfvafnwlGYAnSAmnp 3pblA ( 320 ) vplrekkatqMVaiVlgaFivCWlpFFltHvlnthçqt--------ç-hvspelysattwlGYvNsalNP 2ydv ( 224 ) tlqkevhaakSLaiIvglFalCWlpLHiiNcftffçpd--------çshaplwlMylAivlSHtNSvvNP 3v2w ( 247 ) rssenvaLlkTViiVLsvFiacwapLFiLLllDvgçkvk------tç--diLfrAeyfLvlAvlNSgtNP 4djhA ( 265 ) kdrnlrritrLVlvVVavFvvcWtpIHifilvealgs aalssyyfcIalGytNSslNP 4dkl ( 271 ) kdrnlrritrMVlvVvavFivcWtpIHiyViikaliti-------pettfqtvswhfcialGYtNSclNp 4ej4 ( 252 ) kdrslrriTrMVlvVvgaFvvCWapIHifVivwtlvdi------nrrdplvvaalhlcialGYaNSslNp 4ea3A ( 254 ) kdrnlrritrLVlvVvavFvgcWtpVQvfvlaqglgvq-------pssetavailrfctAlGYvNSclNp 3oduA ( 230 ) kghqkrkalktTviLilaFfacWlpyyigisidsfilleiikqgçefentvhkwisitEAlAFfHCclNp 2lnl ( 233 ) hmgqkhrAmrvIfaVvlifllcwlpynlvlLadTlmrtqviqesçeRrNnIGraLdatEilGflhsclnp 1u19A ( 243 ) tqkaekevTrMviiMviaFliCWlpYAgvAfyIfthqgsd---------fgpifMTipAFfAKtSAvyNP 2z73A ( 252 ) ganaemrlAkIsivIVsqFllSWspYAvvAllAQfgplew---------VtpyaAQlpVMfAKaSaihNP aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaa aaa 360 370 380 390 400 410 3uon ( 438 ) acYalcnatFkktfkhllm 4dajA ( 541 ) vcYalcnktFrttfkt 3rze ( 466 ) liYplCnenFkktfkrilhi 2rh1 ( 324 ) liYc-rspdfriAfqellcl 2vt4A ( 341 ) iiYc-rspdfrkAfkrlla 3pblA ( 381 ) viYttfnieFrkAflkilsc 2ydv ( 286 ) fiyAyrireFrqTFrkiirshvlrqqepfkaa 3v2w ( 309 ) iiytltNkemrrafiri 4djhA ( 328 ) ilYafldenFkrcfrdfcfp 4dkl ( 334 ) vlYafldenFkrCfrefci 4ej4 ( 316 ) vlYaflDenfkrc 4ea3A ( 317 ) ilYafldenFkacfr 3oduA ( 300 ) ilyaflgakfktsaqhalts 2lnl ( 303 ) iiyafigqnfrhgflkilamhg 1u19A ( 304 ) viYimmnkqFrnCmvttlccgknplgddeasttVsktetsqvapa 2z73A ( 313 ) miYsvsHpkFreAIsqtfpwvLtccqfddketeddkdaeteipage aaaaa aaaaaaaaaa