GPCR Structure: Rat neurotensin receptor
Yet another GPCR structure - PDBe code 4grv, the rat neurotensin receptor. The link to the paper is here.
Update - on the first revision of the post, I had word blindness and listed the species as human - it is in fact rat.
%T Structure of the agonist-bound neurotensin receptor %A J.F. White %A N. Noinaj %A Y. Shibata %A J. Love %A B. Kloss %A F. Xu %A J. Gvozdenovic-Jeremic %A P. Shah %A J. Shiloach %A C.G. Tate %A R. Grisshammer %J Nature %V 490 %P 508–513 %D 2012 %O doi:10.1038/nature11558
- 3uon - human muscarinic M2 receptor
- 4daj - rat muscarinic M3 receptor
- 3rze - human histamine H1 receptor
- 2rh1 - human beta-2 adrenergic receptor
- 2vt4 - turkey beta-1 adrenergic receptor
- 3pbl - human dopamine D3 receptor
- 2ydv - human adenosine A2a receptor
- 3v2w - human sphingosine-1-phosphate receptor
- 4djh - human kappa opioid receptor
- 4dkl - mouse mu opioid receptor
- 4ej4 - mouse delta opioid receptor
- 4ea3 - human nociceptin receptor
- 4grv - rat neurotensin receptor
- 3odu - human CXCR4 receptor
- 2lnl - human CXCR1 receptor (NMR)
- 2i35 - bovine rhodopsin
- 2z73 - squid rhodopsin
10 20 30 40 50 60 70 3uon ( 20 ) tfevvfivlvagslSlvTiigNilVmvSIkvnrh 4dajA ( 64 ) iwqvvfiafltgflAlvTiigNilVivAFkvnkq 3rze ( 28 ) mplvvvlsticlvTvglNllVlyAvrserk 2rh1 ( 29 ) devwvvgmgivmslivlaIvfgNvlVitAIakfer 2vt4A ( 40 ) weagmsllmalVvllIvagNvlViaAigstqr 3pblA ( 32 ) yalsYcalilaIvfgNglVcmAVlkera 2ydv ( 3 ) imgssvYitvElaiavlAilgNvlVcwAvwlnsn 3v2w ( 17 ) sdyvnydIIvrHYnyTgklnisa ltsvvfiliCcfIileNifvlltiwktkk 4djhA ( 55 ) spaipviitavysvvfvvGlvgNslVmfVIirytk 4dkl ( 65 ) mvtaitimalYsiVcvvGlfgNflvmyvIvrytk 4ej4 ( 41 ) rsasslalaiaitalYsavcavGllgNvlvmfgIvrytk 4ea3A ( 47 ) plglkvtIvglYlavcvgGllgNclvmyVIlrhtk 4grvA ( 52 ) nsdldVnTdiyskvlvtaiYlalfvvGtvgNsvtlftlark s 3oduA ( 27 ) pçfre-------------------------enanfnkiflptiYsiIfltGivgNglvilvMgyqkk 2lnl ( 29 ) pÇmle--------------------------tetLnkYvviiayalvFllsllgNslvMlvilysrv 1u19A ( 1 ) mnGtegpnfyVPfsnktgvVrsPFeapQyyLaepwqFsmlAayMflLimlGfpiNflTlyVTvqHkk 2z73A ( 9 ) etwwyNpsIvVhpHWref--------------dqvpdavYyslGifIgiCgiiGcggNgiViyLFtktks aaaaaaaaaaaaaaaaaaaaaaaaaaaa 80 90 100 110 120 130 140 150 3uon ( 54 ) LqtvnnyflfSLAcADliiGvfSMnlytlytvi--gyWplgpvvÇdlWlalDYvVSNAsVmNLliiSfdryfcvt 4dajA ( 98 ) LktvnnyFllSLAcADliIGviSMnlFttyiim--nrWalgnlaÇdlwLSiDYvASNAsVmNLlvISfDryfsit 3rze ( 58 ) LhtvGnlYIvsLSvADliVGavVMpmnilyllm--skwsLgrplÇlfWLSmDYVASTASIfSVfiLCiDryrsvq 2rh1 ( 64 ) LqtvtnyFItsLAcADlvMGlaVVpfgaahilm--kmWtfgnfwçefWTSiDVlCVTASIeTLcvIAvdryfAIt 2vt4A ( 72 ) LqtltnlFItsLAcADlvvGllVVpfgatlvvr--gtWlwgsflçelWTSlDVlCVTAsIeTLcvIAiDrylait 3pblA ( 60 ) LqtttnyLVvsLAvADllvAtlVMpwvvylevt-ggvWnfsricÇdvFVTlDVmMcTAsIwNLCaISidRytAVv 2ydv ( 37 ) LqnvtnyFVvsAAaADilVGvlAIpfaiaIst----GfçaaçhgÇLfiACfVLVLTASSIfSLlaIAiDryiair 3v2w ( 76 ) FhrpMYyFIgnLAlSDllaGvaYtaNlllsga---tTykLtPaqWFlREGsMFvALSASVfSLlaIAieryitml 4djhA ( 90 ) mktaTniYIfNLAlADalVTtTMpfqstvylmn---sWpfgdvlÇkiVlsiDyyNMfTSIfTLtmMSvdRyiaVc 4dkl ( 99 ) MktAtniYIfNLAlADalATsTLpfqsvnylmg---tWpfgnilÇkiviSidYyNMFTSIfTLctMSvdRyiAVC 4ej4 ( 80 ) LktATniYIfNLAlADalATstLpfqsakylme---tWpfgellÇkaVlSidYyNMFTSIfTLtmMSvDRyiavc 4ea3A ( 82 ) mktatNiYIfNLAlADtlVLlTLpfQGtdillg---fWpfgnalÇktVIaiDyyNMFTSTfTLtaMSvdryvaic 4grvA ( 98 ) lqstvhyHlgsLalSDllILllAMpvElyNFIWvhhpWafgdagÇrgyYflRDactYATAlNVasLSvaRylAic 3oduA ( 69 ) lrsmtdkYRlhLSvADllFVitLpfWavDAva----nWyfgnflÇkaVHviYTVNlYSSVwILAfISlDRylAiV 2lnl ( 70 ) GrsvTdvyLlnLalaDllfaltlpiwaaSkvn----gwifgtfLÇkvVslLkEvnfYsgilLlacIsvdrylaiv 1u19A ( 68 ) LrtplNyILlnLAvADlfMVfg-GFtTTlyTSl-hGyFvfgptGÇnlEGffATLGGEIaLWSLvvLaieRyvvVc 2z73A ( 65 ) LqtpanmFiinLAfSDftFSlvNGfplMtiSCf-lkkWifgfaaÇkvYGfiGGiFGFMsIMTMAMiSiDrynViG aaaaaaaaaaaaaaaaaa aaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 160 170 180 190 200 210 220 3uon ( 127 ) kpltypvk---rttkmAgmmiaaAwvlSfilwapaIlfwqfivg-----------vrtVedgeÇyIqff------ 4dajA ( 171 ) rpltyrak---rttkrAgvmiglAwviSfvlWApaIlfwqyfvg-----------krtVppgeÇfIqfl------ 3rze ( 131 ) qplrylky---rtktrAsatilgawflSfl-WvipIlgwnh rredkÇeTdfy------ 2rh1 ( 137 ) spfkyqSl---ltknkArviilmvwivSgltSflpIqmhwyr-----athqeAinÇyae-etçÇdff-------- 2vt4A ( 145 ) spfryqsl---mtrarAkviictvwaiSalvSflpImmhwWr-----dedpqAlkçyqd-pgçÇdfv-------- 3pblA ( 134 ) mpvhyqhgtgqsscrrValmitavwvlAfaVSc-pLlfgfNtTg---------------dptvÇsIs-------- 2ydv ( 108 ) iplryngl---vtgtrAkgiiaicwvlSfaIGltPmlgwnnÇgqp--kegkahsqgÇgegqvAÇlFedVV----- 3v2w ( 148 ) k nnfrlfllisacwviSlilGglPimgwn---------------ÇisalssÇSTVLP------- 4djhA ( 162 ) hpvkaldf---rtplkAkiinicIwllSssvGisAivlGGtkvred------------vdvieÇslqFpdddysw 4dkl ( 171 ) hpvkaldf---rtprnAkivnvcNwilSsaiGlpVmfmAttkyrqg--------------sidçtltfsh-ptwy 4ej4 ( 152 ) hpvkaldf---rtpakAklinicIwvlAsgvGvpimvmAvtqprdg--------------avvÇmlqfps-pswy 4ea3A ( 154 ) hp tsskAqavnvaIwalAsvvGvpvaimGsAqvede--------------eieÇlveipt-pqdy 4grvA ( 173 ) hpfkaktl---msrsrtkkfisaIwlaSallAipMlftMGlqnrSadg--------thpgGlVÇTPiv----dta 3oduA ( 140 ) hatn---sqrprkllAekvVyvgVwipAlllT-ipDfif--Anvsead-----------dryiÇdrfyp---ndl 2lnl ( 141 ) haTr----tltqkrhlvkfvclgcwglsmnlS-lpFflf--RQayhpN----------NsSPvÇyEVlg-ndtak 1u19A ( 141 ) kpmsn----frfgenhaimgvafTwvmAlaCAapPlvgwSrYIPE-------------GMQCSÇGIDYYTpheet 2z73A ( 139 ) rpmaas---kkMshrrAfimiifVwlwSvlwAigPifgwGaYtLE-------------GVLCNÇSFdYIsr--ds aaaaaaaaaaaaaaaaaaa aaa 230 240 250 260 270 280 290 300 3uon ( 182 ) snaavtfgtAiaaFylpviiMtvlywhisrasksri pppsrekkvtrtilaIllaF 4dajA ( 226 ) septitfgtAiaaFymPvtiMtilywrIyketek like aqTlsaIllaF 3rze ( 186 ) dvtwfkvmtaiinFylPtllMlwfyakIykaVrqhc lhmnrerkaakQLgfIMaaF 2rh1 ( 195 ) TnqayaiasSivSFyvplviMvfvYsrVfqeakrql kfclkeHkaLktlgiIMgtF 2vt4A ( 203 ) TnrayaiasSiiSFyipLliMifvalrvyreakeq irehkalktlgiImgvF 3pblA ( 185 ) -npdFViySSvvSFylPfgvTvlvyarIyvvlkqrrrk-----------------gvplrekkatqMVaiVlgaF 2ydv ( 173 ) pmnYMVyfNffaCVlvPlllMlgvylrIflaarrqlkqmesq stlqkevhaakSLaiIvglF 3v2w ( 197 ) LYhkhYIlfCTtvFtllllsIvilYcriyslvrtr asrssenvaLlkTViiVLsvF 4djhA ( 222 ) wdlfmkicVfifAfviPvliIivcytlMilrlksvrllsg rekdrnlrritrLVlvVVavF 4dkl ( 228 ) wenllKicVfifAfimPvliItvcyglmilrlksvr ekdrnlrritrMVlvVvavF 4ej4 ( 209 ) wdtvtkicvflfAfvvPiliitvcyglMllrlrsvr ekdrslrriTrMVlvVvgaF 4ea3A ( 211 ) wgpvfaiciflfSFivPvlvIsvcyslMirrlrgvrlls-------------gsrekdrnlrritrLVlvVvavF 4grvA ( 233 ) tvkvvIqvNtfmSFlfPmlvIsilNtvIAnkLtvmv vqalrhGVlvAraVviaf 3oduA ( 195 ) wvvvfqfqhimvglilPgivIlsCyciIisklshs kghqkrkalktTviLilaF 2lnl ( 198 ) wrmvLrilPHtfGfivplfvmlfcygftlrtlf---------------------kahmgqkhrAmrvIfaVvlif 1u19A ( 199 ) nNesFViyMfvvHfiiPlivIffcygqLvftvkeaaaq------------qqesattqkaekevTrMviiMviaF 2z73A ( 196 ) ttrsNIlcMFilGffgPiliiffCyfnIvmsvsnhekemaamakrlnakelrkaqaganaemrlAkIsivIVsqF aaaaaaaaaaa aaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaa 310 320 330 340 350 360 370 3uon ( 397 ) iitWapYNvmVlintfçap--------ç--ipntvwtiGywlCYinstiNpacYalcnatFkktfkhllm 4dajA ( 500 ) iitWtpyNimVlvntfçds--------ç--ipktywnlgywlCYiNStvNPvcYalcnktFrttfkt 3rze ( 425 ) ilCWipYFiffmviafçkn--------ç--cnehlhmftiWlGYiNStlNPliYplCnenFkktfkrilhi 2rh1 ( 283 ) tlcWlpFFiVNivhviqdn----------lirkevyillNwiGYvNSgfNpliYc-rspdfriAfqellcl 2vt4A ( 300 ) tlCWlpFFlvnivnvfnrd----------lvpdwlfvafnwlGYAnSAmnpiiYc-rspdfrkAfkrlla 3pblA ( 339 ) ivCWlpFFltHvlnthçqt--------ç-hvspelysattwlGYvNsalNPviYttfnieFrkAflkilsc 2ydv ( 243 ) alCWlpLHiiNcftffçpd--------çshaplwlMylAivlSHtNSvvNPfiyAyrireFrqTFrkiirshvlr 3v2w ( 266 ) iacwapLFiLLllDvgçkvk------tç--diLfrAeyfLvlAvlNSgtNPiiytltNkemrrafiri 4djhA ( 284 ) vvcWtpIHifilvealgs aalssyyfcIalGytNSslNPilYafldenFkrcfrdfcfp 4dkl ( 290 ) ivcWtpIHiyViikaliti-------pettfqtvswhfcialGYtNSclNpvlYafldenFkrCfrefci 4ej4 ( 271 ) vvCWapIHifVivwtlvdi------nrrdplvvaalhlcialGYaNSslNpvlYaflDenfkrc 4ea3A ( 273 ) vgcWtpVQvfvlaqglgvq-------pssetavailrfctAlGYvNSclNpilYafldenFkacfr 4grvA ( 318 ) vvcWlpYHvRRlmFCyisdeq--WttflFdfYHyfYmlTNalAYasSAinpilYnlvsanFrqv 3oduA ( 249 ) facWlpyyigisidsfilleiikqgçefentvhkwisitEAlAFfHCclNpilyaflgakfktsaqhalts 2lnl ( 252 ) llcwlpynlvlLadTlmrtqviqesçeRrNnIGraLdatEilGflhsclnpiiyafigqnfrhgflkilamhg 1u19A ( 262 ) liCWlpYAgvAfyIfthqgsd---------fgpifMTipAFfAKtSAvyNPviYimmnkqFrnCmvttlccgknp 2z73A ( 271 ) llSWspYAvvAllAQfgplew---------VtpyaAQlpVMfAKaSaihNPmiYsvsHpkFreAIsqtfpwvLtc aaaaaaaaaaaaaaaa aaaaaaaaaaaaa aaaaaaaaa aaaaaaaaaa 380 390 400 410 3uon 4dajA 3rze 2rh1 2vt4A 3pblA 2ydv ( 310 ) qqepfkaa 3v2w 4djhA 4dkl 4ej4 4ea3A 4grvA 3oduA 2lnl 1u19A ( 328 ) lgddeasttVsktetsqvapa 2z73A ( 337 ) cqfddketeddkdaeteipage