GPCR Structure: Muscarinic M3 Receptor

23 Feb 2012

Another GPCR structure! - this time the Rat muscarinic M3 receptor, published in Nature, complexed with the drug tiotropium (CHEMBL1201307).

                           10        20        30        40        50  
4dajA  (  64 )    iwqvvfiafltgflAlvTiigNilVivAFkvnkqLktvnnyFllSLAcAD
                   aaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 333  aaaaaaaaaaaaa

                           60        70        80        90        100 
4dajA  ( 114 )    liIGviSMnlFttyiimnrWalgnlaÇdlwLSiDYvASNAsVmNLlvISf
                  aaaaa aaaaaaaaaaa      aaaaaaaaaaaaaaaaaaaaaaaaaaa

                           110       120       130       140       150 
4dajA  ( 164 )    DryfsitrpltyrakrttkrAgvmiglAwviSfvlWApaIlfwqyfvgkr
                  aaaaaaa          aaaaaaaaaaaaaaaaaaaaaaaaaaaaaa   

                           160       170       180       190       200 
4dajA  ( 214 )    tVppgeÇfIqflseptitfgtAiaaFymPvtiMtilywrIyketek lik
                           333  aaaaaaaaaaa aaaaaaaaaaaaaaaaa       

                           210       220       230       240       250 
4dajA  ( 485 )    e aqTlsaIllaFiitWtpyNimVlvntfçdsçipktywnlgywlCYiNS
                       aaaaaaaaaaaaaaaaaaaaaaaa      aaaaaaaaaaaaaaa

                           260       270 
4dajA  ( 537 )    tvNPvcYalcnktFrttfkt
                  aaaaaaaaaa aaaaaaaa

%A A.C. Kruse
%A J. Hu, Jianxin
%A A.C. Pan
%A D.H. Arlow
%A D.M. Rosenbaum
%A E. Rosemond
%A H.F. Green
%A T. Liu
%A P.S. Chae
%A R.O. Dror
%A D.E. Shaw
%A W.I. Weis
%A J. Wess
%A B.K. Kobilka
%T Structure and dynamics of the M3 muscarinic acetylcholine receptor
%J Nature
%V 482
%P 552-556
%O http://dx.doi.org/10.1038/nature10867