GPCR Structure: Sphingosine-1-phosphate receptor


Hot on the heals of the M2 receptor comes the 3.35A resolution human Sphingosine-1-Phosphate receptor (S1PR, also known as EDG1) - PDBe3v2w - complexed with the ligand {(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl}phosphoric acid. (and also the entry PDBe3v2y)


                          10        20        30        40        50  
3v2w  (  17 )    sdyvnydIIvrHYnyTgklnisa ltsvvfiliCcfIileNifvlltiwk
                       aaaaaaaaaa          aaaaaaaaaaaaaaaaaaaaaaaa

                          60        70        80        90        100 
3v2w  (  73 )    tkkFhrpMYyFIgnLAlSDllaGvaYtaNlllsgatTykLtPaqWFlREG
                  333  aaaaaaaaaaaaaaaaaaaaaaaaa    3333  aaaaaaaaa

                          110       120       130       140       150 
3v2w  ( 123 )    sMFvALSASVfSLlaIAieryitmlk nnfrlfllisacwviSlilGglP
                 aaaaaaaaaaaaaaaaaaaaaaaa       aaaaaaaaaaaaaaaaa  

                          160       170       180       190       200 
3v2w  ( 179 )    imgwnÇisalssÇSTVLPLYhkhYIlfCTtvFtllllsIvilYcriyslv
                          333         aaaaaaaaaaaaaaaaaaaaaaaaaaaaa

                          210       220       230       240       250 
3v2w  ( 229 )    rtr asrssenvaLlkTViiVLsvFiacwapLFiLLllDvgçkvktçdiL
                 aa       aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa        33

                          260       270       280   
3v2w  ( 291 )    frAeyfLvlAvlNSgtNPiiytltNkemrrafiri
                 33 aaaaaaaaa333aaaaaaaaa aaaaaaaa  






%T Crystal Structure of a Lipid G Protein–Coupled Receptor
%A M.A. Hanson
%A C.B. Roth
%A E. Jo
%A M.T. Griffith
%A F.L. Scott
%A G. Reinhart
%A H. Desale
%A B. Clemons
%A S.M. Cahalan
%A S.C. Schuerer
%A M.G. Sanna
%A G.W. Han
%A P. Kuhn
%A H. Rosen
%A R.C. Stevens
%J Science
%V 225
%D 2012
%P 851-855