ChEMBL

Another clutch of turkey beta-1 adrenergic GPCR structures has recently been released (PDBe:2ycw, PDBe:2ycx, PDBe:2ycy and PDBe:2ycz), accompanying a publication in PNAS. These structures contain three different ligands (S-Carazolol, Cyanopindolol and Iodocyanopindalol), and sample new crystal forms, and reveal newly ordered regions not previously observed - these structures represent the fully inactivated R form of the receptor.

%T Two distinct conformations of helix 6 observed in antagonist-bound structures of a β1-adrenergic receptor
%J Proc. Natl. Acad. Sci. USA
%V 108
%P 8228–8232
%D 2011
%A R. Moukhametzianov
%A T. Warne
%A P.C. Edwards
%A M.J. Serrano-Vega
%A A.G.W. Leslie
%A C.G. Tate
%A G.F.X. Schertler

The annotated alignment and spreadsheet of GPCR structures has been updated.