ChEMBL

There are two new kinase inhibitor INNs in the latest WHO list of proposed INNs. (There are other kinase inhibitors in this document, but there are not new INNs/USANs - but if anyone knows anything about pacritinib I'd be glad to hear).



Alisertib a.k.a. MLN-8237 - Millenium's Aurora kinase inhibitor, InChI key: APEDHRWNPCHTHU-UHFFFAOYSA-N InChI: InChI=1S/C27H19ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35) Phase 2



Cenisertib a.k.a. AS-703569 and R-763 - Merck Serono's Aurora kinase inhibitor, InChI key: KSOVGRCOLZZTPF-QMKUDKLTSA-N InChI=1S/C24H30FN7O/c1-14-11-17(5-6-19(14)32-9-7-31(2)8-10-32)28-24-27-13-18(25)23(30-24)29-21-16-4-3-15(12-16)20(21)22(26)33/h3-6,11,13,15-16,20-21H,7-10,12H2,1-2H3,(H2,26,33)(H2,27,28,29,30)/t15-,16+,20+,21-/m1/s1 Phase 1