More GPCR structures...

18 May 2011

Some more structures of a GPCR are available - for the Adenosine A2A receptor complexed to the endogenous ligand adenosine (PDBe:2YDO), and also a further complex with the adenosine analogue NECA (N-ethyl-5'-carboxyamido adenosine) (PDB:2YDV). These structures add significantly to our understanding of the mechanism and structural aspects of agonist signalling.

adenosine

%T Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
%A G. Lebon
%A T. Warne
%A P.C. Edwards
%A K. Bennett
%A C.J. Langmead
%A A.G.W. Leslie
%A C.G. Tate
%J Nature
%D 2011
%O doi:10.1038/nature10136

Update: I've also updated the joy annotated alignment with the new structures (and fixed the ordering to something more usable).