Numbers of drugs by disease area, and patterns in innovation

ChEMBL Rita just knocked this up using Circos and ChEMBL - I am a great boss, and regularly think of things to provide her with therapeutic breaks (pun intended) from her thesis writing.

The graph shows the ATC classes - so A = alimentary, B = blood, C = cardiovascular etc, and specifically the forth level of the ATC classification. The colouring of each segment, is set by the colour of the most recently approved drug within that class. Of course collapsing over the various ATC levels, linkage to target, etc. is also pretty straightforward using the ChEMBL data. A couple of things stand out - the maturity of the cardiovascular drug area C, and by contrast the recent innovation in the oncology and immunology areas L.

More on this, with some refined views on the way soon....

Update - well here is a better view - a lot clearer. Rita - get back to the thesis writing, right now!!


Another update - thanks for the comments on this - here's another one at the top of the ATC hierarchy, this time the new approvals in oncology/immunology as a class stand out more, as does the recent lack of progress and small number of drugs available in the anti-parasitic class.