We used to use Spotfire DecisionSite for data visualisation, and liked it a lot - we've just found out there are some pretty major changes to the licensing; and are now looking for alternatives if we can't work out a way forward. So, any suggestions for good data exploration tools, preferably with some sort of chemistry capabilities. Ideally they would run natively on Mac OsX.
Here's the equivalent view of drug approvals for 2011 so far - pretty similar picture in terms of the distribution of molecule classes - but remember this set of drug approvals, got their USANs assigned, on average about 3 to 4 years ago, so the sets are not strictly comparable, and of course, suffer from small absolute numbers....
The 2011 set of USANs is almost complete, there are 114 of them, but some of these are salts of others, so the total number of distinct potential new drugs is smaller - actually 87 - this is smaller number that previous years. The breakdown by molecule class is quite interesting - remember this set comprise potential future approved drugs, and so, depending on the attrition within each set, the drugs of about three or four years time will look like these.
Small molecules still dominate the set, with almost three quarters of USANs in this class - biologicals are just over one quarter of the cohort.
By rough breakdown, I mean just this, I got out a pencil and a few printed lists and tallied them up - a bigger and better controlled analysis will be posted later.
We would like to announce the release of new version GPCR SARfari. There are many changes to the interface, large increase of data and new functions including GPCR PDB & 3D Model Structures. The model structures were generated for all the GPCR sequences in the database using the latest GPCR PDB structures and the well-considered alignment. You can see & download the models on the protein report page. This version includes:
As part of our tradition of making Xmas seasonal eCards to all our users - above is the December 2012 card. For the geeky amongst you, there may be an Easter Egg in the image file....
Registration is now open for a really interesting EMBO Workshop on the modulation of protein-protein interactions (ppi's). We're speaking, and will present some new stuff on annotation of ChEMBL with interacting domains, and a sort of classification of these into protein-protein interfaces (see some previous blog posts for some further details on this).
The meeting is in the beautiful French harbour town of Roscoff - the traditional home of Onion Johnnies - well, I love onions, and my name is John, and I'll be there!
