Paper: In silico applications of bioisosterism in contemporary medicinal chemistry practice


If you were looking for an up-to-date review of computational applications of bioisosterism in medicinal chemistry, then look no further. After an overview of the history and evolution of bioisosterism, the paper reports the various attempts aiming to capture and quantify it, as well as to disseminate its examples in the context of modern computer-aided drug discovery.

Link to the paper here. 

%A G. Papadatos
%A N. Brown
%T In silico applications of bioisosterism in contemporary medicinal chemistry practice
%J WIREs Computational Molecular Science
%D 2013
%O doi.10.1002/wcms.1148
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