Papers: Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

06 Aug 2011

There's a really interesting paper just published in Science on the screening of the NCGC drug collection against the malaria parasite, it's a tour de force in the application of screening and genomics analysis/exploration of bioactivity data. Amongst the 32 highly actives there are mostly cytotoxic agents, which are probably no big surprise, but a couple of interesting things in there, more later on this (probably...)

Anyway the paper is here.

%T Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets
%J Science
%V 333
%P 724-729
%D 2011
%A J. Yuan
%A K.C.-C. Cheng
%A R.L. Johnson
%A R. Huang
%A S. Pattaradilokrat
%A A. Liu
%A R. Guha
%A D.A. Fidock
%A J. Inglese
%A T.E. Wellems
%A C.P. Austin
%A X.Z Su