ChEMBL

There is an excellent description of specific subtypes of monoclonal antibodies on Wikipedia, these can be easily incorporated into the Drug_Class section of our drug taxonomy. Specifically as Drug_Type_Subsubclass. An interesting property of this classification is that it should be possible to write an algorithm that classifies arbitrary sequences against this taxonomy.

• mab - whole monoclonal antibody.
• Fab - fragment, antigen-binding (one arm).
• F(ab')2 - fragment, antigen-binding, including hinge region (both arms).
• Fab' - fragment, antigen-binding, including hinge region (one arm).
• scFv - single-chain variable fragment.
• di-scFv - dimeric single-chain variable fragment.
• sdAb - single-domain antibody.
• 3funct - trifunctional antibody.
• BiTE - bi-specific T-cell engager.
• Other - an antibody like drug that does not fit one of the above classes.