USAN Watch - April 2012


The USANs for April 2012 have just been published.


USAN Research Code StructureDrug ClassTherapeutic classTarget
alirocumabREGN-727, SAR-0236553mAbtherapeuticPCSK9
birinapantTL-32711synthetic small moleculetherapeuticIAPs
bevenopranCB-5945synthetic small moleculetherapeuticmu opioid receptor
camicinalGSK-962040B

synthetic small moleculetherapeuticmotilin receptor
cindunistatPHA-84250, SC-084250, PF-00572986    synthetic small moleculetherapeuticNOS?
danirixinGSK-1325756B   synthetic small moleculetherapeuticCXCR2
demcizumabOMP-21M18   mAbtherapeuticDLL4
elubrixin, elubrixin tosylateSB-656933-AAF, SB-656933-AAA  synthetic small moleculetherapeuticCXCR2
etirinotecan pegol, etirinotecan pegol tetrahydrochloride, etirinotecan pegol tetratriflutateNKTR-102   natural product-derived small molecule therapeutictopoisomerase 1
fasinumabREGN-475, SAR-164877    mAbtherapeuticNGF
lomibuvirVX-222   synthetic small moleculetherapeuticHCV NS5B polymerase
mafodotinmc-MMAF, mcMMAF, SGD-1269, monomethyl auristatin F

peptidetherapeutictubulin
neceprevirACH-0142684   synthetic small moleculetherapeutic
pexastimogene devacirepvecJX-594   virustherapeutic
rabusertibLY-2603618   synthetic small moleculetherapeuticCHEK1 CHEK2
rilimogene galvacirepvecProstvac-V   virustherapeutic
sebelipase alfaSBC-102   enzymetherapeutic
vercirnonGSK-1605786, CCX-282   synthetic small moleculetherapeuticCCR9
vintafolideEC-145   natural product-derived small moleculetherapeuticFolate Receptor, tubulin
vorsetuzumabSGN-70mAbtherapeuticCD70
vorsetuzumab mafodotinSGN-75 mAb ADCtherapeuticCD70

I knocked this together during a meeting ( :O ) so there may be some errors, feel free to add more detail/corrections in the comments.

A couple of extras have appeared on the USAN web page recently.... so I've updated the table above appropriately. Well, two more have appeared on the USAN site! Will add these soon. It looks like there are some subtle rejigging of the business rules for USANs - in particular the assignment of a USAN for the drug conjugate mafoditin - I do wish that the USAN office would reply to emailed questions.....