USAN Watch - August/September 2012

The USANs for August and September 2012 have recently been published. Sorry for being slow in posting these.... structures will appear over the next few days, and if anyone has the research codes for the various Merck compounds in this list, please post in the comments (telmapitant, vibregon and tildrakizumab).

USANResearch CodeStructureDrug ClassTherapeutic classTarget
aldoxorubicin, aldoxorubicin hydrochlorideINNO-206natural product-derived small moleculetherapeutictopoisomerase II
belnacasan VX-765synthetic small moleculetherapeuticICE-1
deferitazole, deferitazole magnesiumFBS-071, SPD-602synthetic small moleculetherapeuticn/a
delparantag, delparantag pentahydrochloridePMX-60056synthetic small moleculetherapeuticheparin
dupilumab
REGN-668, SAR-231893 
mAbtherapeuticIL4R-alpha
elosulfase alfa
BMN 110, rhGALNS, N-acetylgalactosamine-6-sulfatase,  chondroitinsulfatase, galactose-6-sulfate
sulfatase, EC=3.1.6.4 
enzymetherapeuticn/a
emixustat, emixustat hydrochlorideACU-4429synthetic small moleculetherapeuticRPE-65
empagliflozin 
BI-10773 
synthetic small moleculetherapeuticSGLT2
entolimodCBLB-502proteintherapeuticTLR5
eravacycline TP-434synthetic small moleculetherapeutic30S ribosome
evodenoson
ATL313, DE-112 
synthetic small moleculetherapeuticA2A
filorexant therapeutic
gandotinib
LY-2784544 
synthetic small moleculetherapeuticJAK2


ilorasertib ABT-348, A-968660synthetic small moleculetherapeuticAUR VEGFR SRC
lusutrombopagS-888711synthetic small moleculetherapeutic
mericitabine
RO5024048,  R7128 

synthetic small moleculetherapeuticHCV NS5B polymerase
nelipepimut-s E75 peptide
peptide vaccinetherapeuticHER2
nesvacumab
REGN-910 
mAbtherapeuticangiopoeitin 2
ozanezumab
GSK-1223249 
mAbtherapeuticNogo-A
peginesatide, peginesatide acetate AS-37702, OmontyspeptidetherapeuticEPOr
peginterferon beta-1a BIIB-017proteintherapeuticIFNAR
pidilizumab CT-011mAbtherapeuticPD1
pimasertib

MSC1936369A; AS703026; EMD 1036239 

synthetic small moleculetherapeuticMEK
ramucirumab IMC1121BmAbtherapeuticVEGFR2
rebastinib, rebastinib tosylate
DP-1919.TO, DCC-2036 
synthetic small moleculetherapeuticTie2 TrkA
riociguat
BAY 63-2521 
synthetic small moleculetherapeuticsoluble guanylate cyclase
sofosbuvir
PSI-7977 GS-7977
synthetic small molecule prodrugtherapeuticHCV pol
telmapitant synthetic small moleculetherapeutic
tenofovir alafenamideGS-7340synthetic small molecule prodrugtherapeuticHIV-1 RT
tergenpumatucel-L HALcelltherapeuticn/a
tildrakizumabmAbtherapeuticIL-23
ulodesine, ulodesine succinate
BCX-4208 
synthetic small moleculetherapeuticpurine nucleoside phosphorylase (PNP)
vibegronsynthetic small moleculetherapeutic