ChEMBL

Well, there's a great paper in a recent Nature Reviews Drug Discovery from a cross-industry set of authors on a retrospective analysis of HTS in drug discovery - lots of data, lots of examples, and a balanced argument for the case for high-throughput screening in modern pharmaceutical discovery.

%T Impact of high-throughput screening in biomedical research
%J Nature Rev. Drug Disc.
%V 10
%D 2012 
%P 188-195
%A R. Macarron
%A M.N. Banks
%A D. Bojanic
%A D.J. Burns
%A D.A. Cirovic
%A T. Garyantes
%A D.V.S. Green
%A R.P. Hertzberg
%A W.P. Janzen
%A J.W. Paslay
%A U. Schopfer
%A G.S. Sittampalam